Head of Laboratory:

• László Molnár, MD, PhD, DSc, Professor Emeritus

Researchers:

• Katalin Hegedüs, MD, PhD, Professor
• István Fekete, MD, PhD, Associate Professor

• Development of various experimental stroke models
• Mechanisms and mediators of tissue injury relating to cerebral ischemia
• Study of the effect of combination therapy in experimental stroke models
• Regulation of cerebral blood flow and metabolism in normal and pathological states
• Role of cholinergic and purinergic neurotransmitters in the regulation of cerebral blood flow

• cerebral blood flow (thremoclearance and hydrogen clearance methods)
• cerebral tissue oxygen consumption (polarography)
• EEG (quantitative EEG mapping)
• systemic blood pressure, pulse amplitude and frequency (Statham pressure transducer)
• breathe frequency and amplitude ()
• blood constituents (electrolyt, pH, hematocrit, blood sugar)
• serum adenosine, guanosine, cAMP, cGMP (HPLC, radioimmunoassay)
• image analysis (macroscopic and microscopic computerized densitometry) to quantitation of infarct volume and tissue damage
• light microscopy

Hegedüs K, Fekete I, Tury F, Molnár L:

• Experimental focal cerebral ischaemia in rabbits. J Neurol 1985, 232:223-230

Fekete I, Hegedüs K,Molnár L:

• Cerebral ischemia produced by homologous blood clot emboli in rabbit. J Neurol, 1988, 235:314-317

Molnár L, Hegedüs K, Fekete I:

• A new model for inducing transient cerebral ischemia and subsequent reperfusion in rabbits without craniectomy. Stroke, 1988, 19:1262-1266

Hegedüs K, Vámosi J, Fekete I, Molnár L:

• The size of lesion in various stroke models measured by computerized densitometry. J Cereb Blood Flow Metabol, 1991, 11:S536

Molnár L, Hegedüs K, Fekete I:

• Difference between the cerebrovascular effect of purinergic Co-ATP and that of cholinesterase inhibitor, Physostigmine, in vivo. Eur J Pharmacol 1991, 209:81-86

Hegedüs K, Fekete I, Molnár L:

• Effects of CO₂ inhalation on cerebral blood flow and oxygen tissue level in spontaneously hypertensive rabbits. Stroke, 1992, 23:569-575

Hegedüs K, Fekete I, Molnár L:

• Effects of dipyridamole in spontaneously hypertensive rabbits with diffuse chronic cerebral ischemia. Eur J Pharmacol, 1993, 237:293-298

Hegedüs K, Fekete I, Molnár L:

• Beneficial vascular and metabolic effects of cobalt-ATP in spontaneously hypertensive rabbits with diffuse chronic cerebral ischaemia. J Neurol, 1995, 242:243-248

Hegedüs K, Keresztes T; Fekete I; Molnár L:

• Effect of i.v. dipyridamole on cerebral blood flow, blood pressure, plasma adenosine and cAMP levels in rabbits. J Neurol Sci, 1997, 148: 153-61

Index

• American Heart Association 1997 Heart and Stroke A-Z Guide
• SNACC Bibliography: Start Page
• Cerebral Ischemia Main Page
• Cerebrovascular Disorders

WEB Publication

Stroke - Pathophysiology - Neuroprotection

• American Academy of Neurology - Stroke
• NINDS Stroke Information Guide
• Stroke Guidelines and Practice Parameters -- StrokeCenter at Washington University
• Stroke Scales - StrokeCenter at Washington University
• AHA Scientific Statements--Topic Index
• Stroke
• Acute Ischemic Stroke
• AIC: Cerebral blood flow
• American Scientist Article: The Biophysics of Stroke
• Hemostasis Basics - Programmed Learner
• Cerebral Ischemia
• Neurochemistry of cerebral ischaemia
• PDGF and Neuroprotection
• Neurotrophic Growth Factor - Cerebral Ischemia
• Evidence for hydroxyl radical information during reperfusion....
• Secondary Excitotoxicity
• Sources of Glutamate in Ischemia
• Cerebral Protection
• NTI and Neuroprotection
• The Role of Endothelial Cells in Hypoxia-Induced Cerebral Vasodilation
• Dysfunction of the Endothelial Nitric Oxide Pathway in Diabetes and Hyperglycaemia
• Cytokines on the Web

Neurotransmitters - Ion Channels - Receptors

• Characteristics of NMDA Receptors in the Mammalian Brain
• MBC 3320 Home Page
• Basic Neurochemistry
• Neurotransmitter Store
• Neurotransmitter Lecture
• Glaxo Wellcome pharmacology guide : Neurotransmitters
• Neurotransmitters
• Introduction To Ion Channels
• Ions and Ion Channels Laboratory
• Ion channels
• Ion channel movies
• The definitive internet ion channel guide
• Calcium Channel Blockers
• Na - K ATPase (The Sodium-Potassium ATPase pump)
• Metabotropic Glutamate Receptors
• Adenosine Receptors
• G Protein-Coupled Receptor Main Page
• AUTACOIDS, Part I, Dr. Phillip C. Jobe : Histamine
• Neuroanesthesia Home Page
• G-protein coupled Receptor
• The Basic Neurochemistry Forum
• Adenosine Receptors
• K values for Adenosine A1 receptors
• P2 Purinoceptors
• Pharmacology of Purinergic Receptors
• Pharmacology of P2 Purinergic Receptors
• PURINES AND PYRIMIDINES
• Timmons & Hamilton: Drugs, Brains and Behavior

Neuroimaging

• The Whole Brain Atlas
• CNS Imaging
• Positron Emission Tomography (PET)
• Practice Guidelines for the Use of Imaging in Transient Ischemic Attacks and Acute Stroke
• MR Imaging of Primate Brain
• MR Imaging of Stroke in Rabbits
• CNS SPECT Imaging
• Stroke

Related Abstracts

Researchers - Research Laboratories

Journals

• Journal of Cerebral Blood Flow and Metabolism
• European Journal of Pharmacology
• Free Radical Biology & Medicine
• Journal of Neuroscience Research
• Journal of Physiology (1997)
• Experimental Physiology - Papers
• Publications of the Physiological Society
• Journal of Neurochemistry

Books